RAF Typhoon FGR4s have joined forces with French aircraft in a coordinated attack against an hidden munitions depot in Syria used by the IS group, as stated by the UK Ministry of Defence.
The location, identified by reconnaissance, was believed to be housing weapons and explosive materials, the statement said, and was positioned in mountainous terrain just north of Palmyra in Syria's central region.
"Our fighter planes utilized Paveway IV guided bombs to hit a number of access tunnels leading to the facility... initial indications indicate the objective was successfully hit," the MoD said.
There was no evidence of any civilian casualties in the strike conducted Saturday night and all the aircraft returned to base without incident, the defence officials confirmed.
The British jets were assisted by a Voyager aerial refuelling aircraft.
IS - also known as ISIS - imposed extremist governance over large swathes of Iraq and Syria before its territorial defeat in 2019.
"This action shows our UK leadership, and commitment to stand shoulder to shoulder with our allies, to eradicate any revival of the terrorist group and their violent and radical beliefs in the Middle East," UK Defence Secretary the Defence Secretary stated.
UK warplanes have conducted overwatch operations over Syria to "prevent any efforts to regroup" of Islamic State after its military defeat at the Baghuz confrontation in 2019, the authorities noted.
"I want to thank every member of the UK armed forces involved in this strike for their professionalism and their courage," Healey added. "Including them were a great many British troops on duty over the holidays. This action, to take out dangerous terrorists who endanger our security, shows how our armed forces are ready to step up, all year round, ensuring Britain's security within its borders and powerful internationally."
In December, the US military conducted what it described as a "major assault" against IS targets in the country, following an attack resulted in the deaths of two US servicemembers and a civilian interpreter in Palmyra.
The UN says IS still boasts between 5,000 and 7,000 militants in Syria and Iraq.